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  • 姓名: 陈全姣
  • 性别: 女
  • 职称: 研究员(自然科学)
  • 职务: 研究员
  • 学历: 博士研究生
  • 电话: 027-87198167
  • 传真: 
  • 电子邮件: chenqj@wh.iov.cn
  • 所属部门: 流感病毒学科组
  • 通讯地址: 湖北省武汉市武昌小洪山中区44号

    简  历:

  •       陈全姣,博士,研究员。现任武汉病毒所流感病毒学科组长。1997年及2003年于华中农业大学动物医学学院获得学士及硕士学位,2007年于中国科学院武汉病毒研究所获博士学位。主要研究方向为自然感染状态下流感病毒的生物学特征;流感病毒感染致病机制及致死宿主细胞途径及分子细节;Nipah病毒致病机理。主持的项目(课题)包括科技部“973”项目子课题,国家科技重大专项,国家自然科学基金面上和青年基金,多项企业产品体内和体外抗流感病毒药效评价课题等。在Cell Host & Microbe, Clinical infectious diseases, Journal of Virology, Emerg Microbes Infect, Infect Genet Evol和J Gen Virol等国际学术期刊发表代表性通讯作者论文。曾获山东省科学技术二等奖。    

    社会任职:

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    研究方向:

  • 自然感染状态下流感病毒的生物学特征;流感病毒感染致病机制及致死宿主细胞途径及分子细节;新型流感病毒疫苗设计。

    承担科研项目情况:

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    代表论著:

  • 1.    Yuhai Bi*#, Juan Li#, Shanqin Li#, Guanghua Fu#, Tao Jin#, Cheng Zhang, Yongchun Yang, Zhenghai Ma, Wenxia Tian, Jida Li, Shuqi Xiao, Liqiang Li, Renfu Yin, Yi Zhang, Lixin Wang, Yantao Qin, Zhongzi Yao, Fanyu Meng, Dongfang Hu, Delong Li, Gary Wong, Fei Liu, Na Lv, Liang Wang, Lifeng Fu, Yang Yang, Yun Peng, Jinmin Ma, Kirill Sharshov, Alexander Shestopalov , Marina Gulyaeva , George F Gao, Jianjun Chen, Yi Shi , William J Liu, Dong Chu, Yu Huang, Yingxia Liu , Lei Liu , Wenjun Liu , Quanjiao Chen* , Weifeng Shi*. Dominant subtype switch in avian influenza viruses during 2016-2019 in China. Nat Commun. 2020 Nov 20;11(1):5909. (Co-corresponding author)

    2.    Qun Qian, Lifang Fan, Weicheng Liu, Jin Li, Junqiu Yue, Mingwei Wang,

    Xianliang Ke, Yan Yin, Quanjiao Chen*, Congqing Jiang*. Direct evidence of active SARS-CoV-2 replication in the intestine. Clin Infect Dis. 2020 Jul 8:ciaa925. (Co-corresponding author)

    3.    Liping Ma, Zhen Chen, Wuxiang Guan, Quanjiao Chen*, Di Liu*. Rapid and Specific Detection of All Known Nipah virus Strains’ Sequences With Reverse Transcription-Loop-Mediated Isothermal Amplification. Front. Microbiol. 2019, 10:418. (Co-corresponding author)

    4.    Liping Ma , Tao Jin, Hanzhong Wang, Haizhou Liu, Runkun Wang, Yong Li, Guoxiang Yang, Yanping Xiong, Jing Chen, Jun Zhang, Guang Chen, Wei Li, Di Liu, Peng Lin, Yueying Huang, George F Gao, Quanjiao Chen*. Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. Emerg Microbes Infect. 2018 Feb 7;7(1):14. (Corresponding author)

    5.    Quanjiao Chen, Hanzhong Wang, Lihua Zhao, Liping Ma, Runkun Wang, Yongsong Lei, Yong Li, Guoxiang Yang, Jing Chen, Guang Chen, Liqiang Li, Tao Jin, Jiandong Li, Xin Liu, Xun Xu, Gary Wong, Lei Liu, Yingxia Liu, Weifeng Shi, Yuhai Bi, George F Gao. First documented case of avian influenza (H5N1) virus infection in a lion. Emerg Microbes Infect. 2016 Dec 21;5(12):e125.

    6.    Kun Mei, Guang Liu, Zhenzhen Chen, Zhimin Gao, Lihua Zhao, Tao Jin, Xiaolan Yu, Quanjiao Chen*. Deep sequencing reveals the viral adaptation process of environment-derived H10N8 in mice. Infect Genet Evol. 2016 Jan; 37:8-13. (Co-corresponding author)

    7.    Yuhai Bi#, Quanjiao Chen#, Qianli Wang#, Jianjun Chen#, Tao Jin, Gary Wong, Chuansong Quan, Jun Liu, Jun Wu, Renfu Yin, Lihua Zhao, Mingxin Li, Zhuang Ding, Rongrong Zou, Wen Xu, Hong Li, Huijun Wang, Kegong Tian, Guanghua Fu, Yu Huang, Alexander Shestopalov, Shoujun Li, Bing Xu, Hongjie Yu, Tingrong Luo, Lin Lu, Xun Xu, Yang Luo, Yingxia Liu, Weifeng Shi, Di Liu, George Fu Gao. Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China. Cell Host & Microbe. 2016 Dec 14; 20(6):810-821. (Co-first author)

    8.    Yuhai Bi, Haizhou Liu, Chaochao Xiong, Di Liu, Weifeng Shi, Mingxin Li, Siling Liu, Jing Chen, Guang Chen, Yong Li, Guoxiang Yang, Yongsong Lei, Yanping Xiong, Fumin Lei, Hanzhong Wang, Quanjiao Chen*, Jianjun Chen and George F Gao. Novel avian influenza A (H5N6) viruses isolated in migratory waterfowl before the first human case reported in China, 2014. Scientific Reports. Sci Rep 2016 Jul 19;6:29888 (Co-corresponding author)

    9.    Bi Y, Xiao H, Chen Q*, Wu Y, Fu L, Quan C, Wong G, Liu J, Haywood J, Liu Y, Zhou B, Yan J, Liu W, Gao GF.Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice. J Virol. 2015 Dec 9;90(4):2142-9. (Co-first author)

    10.  Bi Y, Mei K, Shi W, Liu D, Yu X, Gao Z, Zhao L, Gao GF, Chen J, Chen Q*. Two Novel Reassortants of Avian Influenza A(H5N6) Virus in China. J Gen Virol. 2015, 96(Pt 5): 975-81.  (Co-corresponding author)

    11.  Chen Q*, Huang S, Chen J, Zhang S, Chen Z*. NA proteins of influenza A viruses H1N1/2009, H5N1, and H9N2 show differential effects on infection initiation, virus release, and cell-cell fusion. PLoS One. 2013; 8(1): e54334.

    12.  Huang S, Chen J, Chen Q, Wang H, Yao Y, Chen J, Chen Z*. A second CRM1-dependent nuclear export signal in the influenza A virus NS2 protein contributes to the nuclear export of viral ribonucleoproteins. J Virol. 2013; 87(2): 767-78.

    专利申请:

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    获奖及荣誉:

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