Title: Principal Investigator E-mail: liud@wh.iov.cn


09/2000 - 07/2005, College of Life Sciences, Peking University, Beijing, Ph. D. degree in Bioinformatics
09/1996 - 07/2000, Department of Physiology and Biophysics, College of Life Sciences, Peking University, Beijing, B. Sc. Degree

Research Interests

Microbial genomic and meta-genomic analyses

Bioinformatics analyses on pathogenic microbes

Database and applications for DNA barcode

Biological database and software development



1.   Du P, Ding N, Li J, Zhang F, Wang Q, Chen Z, Song C, Han K, Xie W, Liu J, Wang L, Wei L, Ma S, Hua M, Yu F, Wang L, Wang W, An K, Chen J, Liu H, Gao G, Wang S, Huang Y, Wu AR, Wang J, Liu D, Zeng H, Chen C. Genomic surveillance of COVID-19 cases in Beijing. Nature communications11(1), 5503. doi: 10.1038/s41467-020-19345-0. PMID: 33127911; PMCID: PMC7603498. (IF=12.121)


2.   Cao, Y., Sun, Y., Tian, X., Bai, Z., Gong, Y., Qi, J., Liu, D., Liu, W., & Li, J. (2020). Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species. Frontiers in veterinary science7, 457. https://doi.org/10.3389/fvets.2020.00457 (IF=2.245)


3.   Cao, Y., Li, W., Chu, X., Wu, K., Liu, H., & Liu, D. (2020). Sheng wu gong cheng xue bao = Chinese journal of biotechnology36(5), 811–819. https://doi.org/10.13345/j.cjb.190368


4.   Jia, L., Chen, J., Liu, H., Fan, W., Wang, D., Li, J., & Liu, D. (2020). Potential m6A and m5C Methylations within the Genome of A Chinese African Swine Fever Virus Strain. Virologica Sinica, 10.1007/s12250-020-00217-2. Advance online publication. https://doi.org/10.1007/s12250-020-00217-2 (IF=3.242)


5.   Fadlallah, G. M., Ma, F., Zhang, Z., Hao, M., Hu, J., Li, M., Liu, H., Liang, B., Yao, Y., Gong, R., Zhang, B., Liu, D., & Chen, J. (2020). Vaccination with Consensus H7 Elicits Broadly Reactive and Protective Antibodies against Eurasian and North American Lineage H7 Viruses. Vaccines8(1), 143. https://doi.org/10.3390/vaccines8010143 (IF=4.086)


6.   Lu, X., Zhang, L., Du, H., Zhang, J., Li, Y. Y., Qu, J., Zhang, W., Wang, Y., Bao, S., Li, Y., Wu, C., Liu, H., Liu, D., Shao, J., Peng, X., Yang, Y., Liu, Z., Xiang, Y., Zhang, F., Silva, R. M., … Chinese Pediatric Novel Coronavirus Study Team (2020). SARS-CoV-2 Infection in Children. The New England journal of medicine382(17), 1663–1665. https://doi.org/10.1056/NEJMc2005073 (IF=74.699)


7.   Wang, M., Qiu, Y., Liu, H., Liang, B., Fan, B., Zhou, X., & Liu, D. (2020). Transcription profile of human endogenous retroviruses in response to dengue virus serotype 2 infection. Virology544, 21–30. https://doi.org/10.1016/j.virol.2020.01.014 (IF=2.819)


8.   Sun, B., Zhang, X., Zhang, H., Liu, H., Sun, L., Tan, Q., Liang, M., Wu, D., & Liu, D. (2020). Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. PLoS neglected tropical diseases14(3), e0008049. https://doi.org/10.1371/journal.pntd.0008049 (IF=3.885)


9.    Yu, F., Yan, Y., Shi, M., Liu, H. Z., Zhang, H. L., Yang, Y. B., Huang, X. Y., Gauger, P. C., Zhang, J., Zhang, Y. H., Tong, G. Z., Tian, Z. J., Chen, J. J., Cai, X. H., Liu, D., Li, G., & An, T. Q. (2020). Phylogenetics, Genomic Recombination, and NSP2 Polymorphic Patterns of Porcine Reproductive and Respiratory Syndrome Virus in China and the United States in 2014-2018. Journal of virology94(6), e01813-19. https://doi.org/10.1128/JVI.01813-19 (IF=4.501)


10. Wang, Z., Jia, L., Li, J., Liu, H., & Liu, D. (2020). Pan-Genomic Analysis of African Swine Fever Virus. Virologica Sinica35(5), 662–665. https://doi.org/10.1007/s12250-019-00173-6 (IF=3.242)


11.  Jia, L., Jiang, M., Wu, K., Hu, J., Wang, Y., Quan, W., Hao, M., Liu, H., Wei, H., Fan, W., Liu, W., Hu, R., Wang, D., Li, J., Chen, J., & Liu, D. (2020). Nanopore sequencing of African swine fever virus. Science China. Life sciences63(1), 160–164. https://doi.org/10.1007/s11427-019-9828-1 (IF=4.611)


12. Chen, J., Huang, C., Zhang, Y., Zhang, S., & Jin, M. (2020). Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies in Pets in Wuhan, China. The Journal of infection81(3), e68–e69. https://doi.org/10.1016/j.jinf.2020.06.045 (IF=4.842)


13. Zheng, X., Wang, H., Su, Z., Li, W., Yang, D., Deng, F., & Chen, J. (2020). Co-infection of SARS-CoV-2 and Influenza virus in Early Stage of the COVID-19 Epidemic in Wuhan, China. The Journal of infection81(2), e128–e129. https://doi.org/10.1016/j.jinf.2020.05.041 (IF=4.842)


14. Yuan, J., Chen, C., Cui, J., Lu, J., Yan, C., Wei, X., Zhao, X., Li, N., Li, S., Xue, G., Cheng, W., Li, B., Li, H., Lin, W., Tian, C., Zhao, J., Han, J., An, D., Zhang, Q., Wei, H., … Liu, D. (2019). Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae. Cell metabolism30(4), 675–688.e7. https://doi.org/10.1016/j.cmet.2019.08.018 (IF=21.567)


15. Cao, Y., Li, J., Chu, X., Liu, H., Liu, W., & Liu, D. (2019). Nanopore sequencing: a rapid solution for infectious disease epidemics. Science China. Life sciences62(8), 1101–1103. https://doi.org/10.1007/s11427-019-9596-x (IF=4.611)


16. Chen, J., Liang, B., Hu, J., Liu, H., Sun, J., Li, M., Chen, Q., He, Y., & Liu, D. (2019). Circulation, Evolution and Transmission of H5N8 virus, 2016-2018. The Journal of infection79(4), 363–372. https://doi.org/10.1016/j.jinf.2019.07.005 (IF=4.842)


17. Tian, G., Wu, C., Li, J., Liang, B., Zhang, F., Fan, X., Li, Z., Wang, Y., Li, Z., Liu, D., Lai-Han Leung, E., & Chen, J. (2019). Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis. Pharmacological research144, 158–166. https://doi.org/10.1016/j.phrs.2019.04.012 (IF=5.893)


18. Ma, L., Chen, Z., Guan, W., Chen, Q., & Liu, D. (2019). Rapid and Specific Detection of All Known Nipah virus Strains' Sequences With Reverse Transcription-Loop-Mediated Isothermal Amplification. Frontiers in microbiology10, 418. https://doi.org/10.3389/fmicb.2019.00418 (IF=4.235)


19. Ma, L., Liu, H., Wang, R., Jin, T., Liu, D., Gao, G. F., & Chen, Q. (2019). Low Pathogenic Avian Influenza A (H5N7) Virus Isolated from a Domestic Duck in Dongting Lake Wetland of China, 2016. Virologica Sinica34(1), 97–101. https://doi.org/10.1007/s12250-018-0081-7 (IF=3.242)


20. Fei, Y., Liu, X., Mu, J., Li, J., Yu, X., Chang, J., Bi, Y., Stoeger, T., Wajid, A., Muzyka, D., Sharshov, K., Shestopalov, A., Amonsin, A., Chen, J., Ding, Z., & Yin, R. (2019). The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype. Viruses11(7), 646. https://doi.org/10.3390/v11070646 (IF=3.816)


21. Yao, Y., Wang, H., Chen, J., Shao, Z., He, B., Chen, J., Lan, J., Chen, Q., & Chen, Z. (2019). Protection against homo and hetero-subtypic influenza A virus by optimized M2e DNA vaccine. Emerging microbes & infections8(1), 45–54. https://doi.org/10.1080/22221751.2018.1558962 (IF=5.776)


22. Ni, M., Chen, C., & Liu, D. (2018). An Assessment of Amplicon-Sequencing Based Method for Viral Intrahost Analysis. Virologica Sinica, 33(6), 557–560. https://doi.org/10.1007/s12250-018-0052-z (IF=3.242)


23. Sun, B., Jia, L., Liang, B., Chen, Q., & Liu, D. (2018). Phylogeography, Transmission, and Viral Proteins of Nipah Virus. Virologica Sinica33(5), 385–393. https://doi.org/10.1007/s12250-018-0050-1 (IF=3.242)


24. Chen, C., Jiang, D., Ni, M., Li, J., Chen, Z., Liu, J., Ye, H., Wong, G., Li, W., Zhang, Y., Wang, B., Bi, Y., Chen, D., Zhang, P., Zhao, X., Kong, Y., Shi, W., Du, P., Xiao, G., Ma, J., … Liu, D. (2018). Phylogenomic analysis unravels evolution of yellow fever virus within hosts. PLoS neglected tropical diseases12(9), e0006738. https://doi.org/10.1371/journal.pntd.0006738 (IF=3.885)


25. Liu, H., Xiong, C., Chen, J., Chen, G., Zhang, J., Li, Y., Xiong, Y., Wang, R., Cao, Y., Chen, Q., Liu, D., Wang, H., & Chen, J. (2018). Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China. Emerging microbes & infections7(1), 62. https://doi.org/10.1038/s41426-018-0064-7 (IF=5.776)


26. Liu, D., Bu, D., Shi, T., Quan, J., Wang, D., Shi, Y., Bo, X. C., & Han, W. (2018). Biological data processing based on bio-processor unit (BPU), a new concept for next generation computational biology. Science China. Life sciences61(5), 597–598. https://doi.org/10.1007/s11427-018-9278-3 (IF=4.611)


27. Ma, L., Jin, T., Wang, H., Liu, H., Wang, R., Li, Y., Yang, G., Xiong, Y., Chen, J., Zhang, J., Chen, G., Li, W., Liu, D., Lin, P., Huang, Y., Gao, G. F., & Chen, Q. (2018). Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. Emerging microbes & infections7(1), 14. https://doi.org/10.1038/s41426-017-0012-y (IF=5.776)


28. Qi, M., Zhang, X. E., Sun, X., Zhang, X., Yao, Y., Liu, S., Chen, Z., Li, W., Zhang, Z., Chen, J., & Cui, Z. (2018). Intranasal Nanovaccine Confers Homo- and Hetero-Subtypic Influenza Protection. Small (Weinheim an der Bergstrasse, Germany)14(13), e1703207. https://doi.org/10.1002/smll.201703207 (IF=11.459)


29. Liu, W. J., & Liu, D. (2017). The triphibious warfare against viruses. Science China. Life sciences, 60(12), 1295–1298. https://doi.org/10.1007/s11427-017-9252-y (IF=4.611)