Title: Principal Investigator E-mail:


2000.09-2004.07, Henan University, Bachelor of Engineering, Bioengineering
2004.09-2010.12, Wuhan Institute of Virology, Chinese Academy of Sciences, PhD, Biochemistry and Molecular Biology
2009.09-2010.09, Australian Animal Health Laboratory, Ph.D.(Joint Training of CSC Program),Viral Immunology

Research Interests
Bat innate immunity; virus host interface; pathogens discovery


1.        Zhou, P., Shi, Z.L*. (2021). SARS-CoV-2 spillover events. Science. 371(6525):120-122.

2.        Shu, H., Wang, S., Ruan, S., Wang, Y., Zhang, J., Yuan, Y., Liu, H., Wu, Y., Li, R., Pan, S., Ouyang, Y., Yuan, S., Zhou, P.*, Shang, Y*. (2020). Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak. Virol Sin. 35(6):744-751.

3.        Yue, H., Zhang, M., Xing, L., Wang, K., Rao, X.*, Liu, H.*, Tian, J.*, Zhou, P.*, Deng, Y.*, Shang, J*. (2020). The epidemiology and clinical characteristics of co-infection of SARS-CoV-2 and influenza viruses in patients during COVID-19 outbreak. J Med Virol. 92(11):2870-2873.

4.        Wei, Y., Lu, Y., Xia, L., Yuan, X., Li, G.*, Li, X.*, Liu, L.*, Liu, W.*, Zhou, P.*, Wang, C-Y.*, Zhang, H*. (2020). Analysis of 2019 novel coronavirus infection and clinical characteristics of outpatients: An epidemiological study from a fever clinic in Wuhan, China. J Med Virol. 92(11):2758-2767.

5.        Zhang, H.*, Zhou, P.*, Wei, Y.*, Yue, H.*, Wang, Y.*, Hu, M.*, Zhang, S., Cao, T., Yang, C., Li, M., Guo, G., Chen, X., Chen, Y., Lei, M., Liu, H., Zhao, J., Peng, P., Wang, C-Y., Du, R. (2020). Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19. Ann Intern Med. 172(9):629-632.

6.        Li, Q.#, Zheng, X-S.#, Shen, X-R., Si, H-R., Wang, X., Wang, Q., Li, B., Zhang, W., Zhu, Y., Jiang, R-D., Zhao, K., Wang, H., Shi, Z-L., Zhang, H-L.*, Du, R-H.*, Zhou, P*. (2020). Prolonged shedding of severe acute respiratory syndrome coronavirus 2 in patients with COVID-19. Emerg Microbes Infect. 9(1):2571-2577.

7.        Hu, B.#, Guo, H.#, Zhou, P., Shi, Z.L*. (2020). Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 19(3):141-154.

8.        Li, S.#, Zhang, Y.#, Guan, Z.#, Li, H., Ye, M., Chen, X., Shen, J., Zhou, Y., Shi, Z.L., Zhou, P.*, Peng, K*. (2020). SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation. Signal Transduct Target Ther. 5(1):235.

9.        Shan, C.#*, Yao, Y.F.#, Yang, X.L.#, Zhou, Y.W.#, Gao, G., Peng, Y., Yang, L., Hu, X., Xiong, J., Jiang, R.D., Zhang, H.J., Gao, X.X., Peng, C., Min, J., Chen, Y., Si, H.R., Wu, J., Zhou, P., Wang, Y.Y., Wei, H.P., Pang, W., Hu, Z.F., Lv, L.B., Zheng, Y.T., Shi, Z.L.*, Yuan, Z.M*. (2020). Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. Cell Res. 30(8):670-677.

10.    Jiang, R.D.#, Liu, M.Q.#, Chen, Y.#, Shan, C., Zhou, Y.W., Shen, X.R., Li, Q., Zhang, L., Zhu, Y., Si, H.R., Wang, Q., Min, J., Wang, X., Zhang, W., Li, B., Zhang, H.J., Baric, R.S., Zhou, P., Yang, X.L.*, Shi, Z.L*. (2020). Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. Cell. 182(1):50-58.e8.

11.    Zhou, P.#, Yang, X.L.#, Wang, X.G.#, Hu, B., Zhang, L., Zhang, W., Si, H.R., Zhu, Y., Li, B., Huang, C.L., Chen, H.D., Chen, J., Luo, Y., Guo, H., Jiang, R.D., Liu, M.Q., Chen, Y., Shen, X.R., Wang, X., Zheng, X.S., Zhao, K., Chen, Q.J., Deng, F., Liu, L.L., Yan, B., Zhan, F.X., Wang, Y.Y., Xiao, G.F., Shi, Z.L*.  (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 579(7798):270-273.

12.    Zhang, W.#, Du, R.H.#, Li, B., Zheng, X.S., Yang, X.L., Hu, B., Wang, Y.Y., Xiao, G.F., Yan, B., Shi, Z.L.*, Zhou, P*. (2020). Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 9(1):386-389.

13.    Li, B.#, Si, H.R.#, Zhu, Y., Yang, X.L., Anderson, D.E., Shi, Z.L., Wang, L.F.*, Zhou, P*. (2020). Discovery of Bat Coronaviruses through Surveillance and Probe Capture-Based Next-Generation Sequencing. mSphere. 5(1):pii: e00807-19.

14.    Zhang, W.#, Zheng, X.S.#, Agwanda, B.#, Ommeh, S.#, Zhao, K., Lichoti, J., Wang, N., Chen, J., Li, B., Yang, X.L., Mani, S., Ngeiywa, K.J., Zhu, Y., Hu, B., Onyuok, S.O., Yan, B., Anderson, D.E., Wang, L.F., Zhou, P.*, Shi, Z.L*. (2019). Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels. Emerg Microbes Infect. 8(1):1528-1534.

15.    Fan, Y., Zhao, K., Shi, Z.L., Zhou, P*. (2019). Bat Coronaviruses in China. Viruses-Basel. 11(3):210.

16.    Yang, X.L.#, Tan, C.W.#, Anderson, D.E., Jiang, R.D., Li, B., Zhang, W., Zhu, Y., Lim, X.F., Zhou, P., Liu, X.L., Guan, W., Zhang, L., Li, S.Y., Zhang, Y.Z., Wang, L.F.*, Shi, Z.L*. (2019). Characterization of a filovirus (Měnglà virus) from Rousettus bats in China. Nat Microbiol. 4(3):390-395.

17.    Zhou, P.#, Fan, H.#, Lan, T.#, Yang, X-L, Shi, W-F, Zhang, W., Zhu. Y., Zhang, Y-W., Xie, Q-M., Mani, S., Zheng, X-S., Li, B., Li, J-M., Guo, H., Pei, G-Q., An, X-P., Chen J-W., Zhou, L., Mai, K-J., Wu, Z-X., Li, D., Anderson, D.E., Zhang, L-B., Li, S-Y., Mi, Z-Q., He, T-T., Cong, F., Guo, P-J., Huang, R., Luo, Y., Liu, X-L., Chen, J., Huang, Y., Sun, Q., Zhang, X-L-L., Wang, Y-Y., Xing, S-Z., Chen, Y-S., Sun, Y., Li, J., Daszak, P.*, Wang, L-F.*, Shi, Z-L.*, Tong, Y-G.*, Ma, J-Y*. (2018). Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin. Nature. 556(7700):255-258.

18.    Xie, J., Li, Y., Shen, X., Goh, G., Zhu, Y., Cui, J., Wang, L-F., Shi, Z.L.*, Zhou, P*. (2018). Dampened STING-Dependent Interferon Activation in Bats. Cell Host Microbe. 23(3):297-301.

19.    Zhang, Q., Zeng, L.P., Zhou, P., Irving, A.T., Li, S., Shi, Z.L.*, Wang, L.F. (2017). IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection. PLoS One. 12(8):e0182866.

20.    Zhou, P., Chionh, Y.T., Irac, S.E., Ahn, M., Ng, J.H., Fossum, E., Bogen, B.,  Ginhoux, F., Irving, A.T.*, Dutertre, C.A.*, & Wang, L.F. (2016). Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages. Sci Rep. 6:38597.

21.    Zhou, P.*, Tachedjian, M., Wynne, J.W., Boyd, V., Cui, J., Smith, I., Cowled, C., Ng, J.H., Mok, L., Michalski, W.P., Mendenhall, I.H., Tachedjian, G., Wang, L.F., Baker, M.L*. (2016). Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats. Proc Natl Acad Sci U S A. 113(10):2696-701.