袁帅

姓   名： 袁帅

职称职务： 研究员，学科组长

电子邮箱：yuanshuai@wh.iov.cn

研究方向

利用冷冻电镜单颗粒重构等结构生物学技术，结合分子生物学、病毒学等研究手段，研究重要病原的入侵、蛋白表达调控、颗粒重组等关键步骤的工作机制，为药物设计提供线索与理论依据。

教育及工作经历

2008.09-2012.07 中国科学技术大学 生命科学 学士

2012.09-2018.01 中国科学院生物物理研究生 生物化学与分子生物学 博士

2018.07-2021.07 耶鲁大学医学院（美国） 博士后

2021.09-至今     中国科学院武汉病毒研究所 研究员

近五年承担项目

近五年代表性论文

[1] S. Yuan*, J. Wang*, D. Zhu*, N. Wang, Q. Gao, W. Chen, H. Tang, J. Wang, X. Zhang, H. Liu, Z. Rao and X. Wang. Cryo-EM structure of a herpesvirus capsid at 3.1 A [J]. Science, 2018, 360(6384):

[2] J. Wang*, S. Yuan*, D. Zhu*, H. Tang, N. Wang, W. Chen, Q. Gao, Y. Li, J. Wang, H. Liu, X. Zhang, Z. Rao and X. Wang. Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component [J]. Nat Commun, 2018, 9(1): 3668.

[3] S. Yuan*, L. Peng*, J. J. Park, Y. Hu, S. C. Devarkar, M. B. Dong, Q. Shen, S. Wu, S. Chen, I. B. Lomakin and Y. Xiong. Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA [J]. Mol Cell, 2020, 80(6): 1055-66 e6.

[4] S. Yuan, L. Cao, H. Ling, M. Dang, Y. Sun, X. Zhang, Y. Chen, L. Zhang, D. Su, X. Wang and Z. Rao. TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope [J]. Protein Cell, 2015, 6(11): 814-24.

[5] S. Yuan, S. Balaji, I. B. Lomakin and Y. Xiong. Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition [J]. Front Microbiol, 2021, 12(2683):

[6] S. Yuan, K. Fan, Z. Chen, Y. Sun, H. Hou and L. Zhu. Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design [J]. Virol Sin, 2020, 35(4): 445-54.

[7] Y. Sun*, X. Wang*, S. Yuan, M. Dang, X. Li, X. C. Zhang and Z. Rao. An open conformation determined by a structural switch for 2A protease from coxsackievirus A16 [J]. Protein Cell, 2013, 4(10): 782-92.

[8] X. Wang*, L. Zhu*, M. Dang*, Z. Hu, Q. Gao, S. Yuan, Y. Sun, B. Zhang, J. Ren, A. Kotecha, T. S. Walter, J. Wang, E. E. Fry, D. I. Stuart and Z. Rao. Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site [J]. Proc Natl Acad Sci U S A, 2017, 114(4): 770-5.

[9] L. Zhu*, X. Wang*, J. Ren, A. Kotecha, T. S. Walter, S. Yuan, T. Yamashita, T. J. Tuthill, E. E. Fry, Z. Rao and D. I. Stuart. Structure of human Aichi virus and implications for receptor binding [J]. Nat Microbiol, 2016, 1(11): 16150.

[10]     X. Wang*, S. H. Li*, L. Zhu*, Q. G. Nian, S. Yuan, Q. Gao, Z. Hu, Q. Ye, X. F. Li, D. Y. Xie, N. Shaw, J. Wang, T. S. Walter, J. T. Huiskonen, E. E. Fry, C. F. Qin, D. I. Stuart and Z. Rao. Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability [J]. Nat Commun, 2017, 8(1): 14.