姓 名:张先恩 职称职务:研究员
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研究方向 采用分子工程学、纳米生物学和合成生物学方法,构建细胞传感器、分子传感器与分子影像、酶传感器等,用于解决病原微生物及病毒学、肿瘤学的基础与临床问题。 教育及工作经历 | |
1982年 湖北大学,生物学,学士 1985年 中科院武汉病毒所,微生物学,硕士学位 1995年 中科院微生物所,生物化学,博士学位 1985年 中科院武汉病毒所从事科研,研究员(1993) 1992年 先后任中科院武汉病毒所副所长、中科院武汉分院党组书记及副院长科学技术部基础研究司司长 2013年-至今 中科院生物物理所任研究员,并任武汉病毒所兼职研究生导师、学术委员会主任(-2018) 近五年承担项目 | |
1、中科院战略性先导专项(B类); 2、中科院应急攻关项目; 3、国家自然科学基金重大项目; 4、国家重点研发计划纳米科技专项; 近五年代表性论文 1.Minhai Chen, Chuang Yan, Yingxin Ma, Xian-En Zhang*. System with Enhanced Fluorescence for Imaging Protein–Protein Interactions In Vivo. Biomaterials, 2020, 268. 2.Netrapal Singh, Lin Huang, Dian-Bing Wang, Nan Shao, Xian-En Zhang*. Simultaneous Detection of a Cluster of Differentiation Markers on Leukemia-Derived Exosomes by Multiplex Immuno-Polymerase Chain Reaction via Capillary Electrophoresis Analysis. Analytical Chemistry, 2020, 92(15):10569-10577. 3.Song Lu, Dian-Bing Wang, Yu Hou, Dongge Guo, Yulin Deng*, Xian-En Zhang*. Illuminating single genomic loci in live cells by reducing nuclear background fluorescence. Science China-Life Sciences, 2020, doi: 10.1007/s11427-020-1794-2. 4.Chenchen Xu, Weiwei Zhu, Hanjin Mao, Wenjing Zhang, Gen-Quan Yin, Xian-En Zhang*, Feng Li*. Switch from Polymorphic to Homogenous Self-Assembly of Virus-Like Particles of Simian Virus 40 through Double-Cysteine Substitution. SMALL, DOI: 10.1002/smll.202004484. 5.Wei Feng, Ashley M. Newbigging, Connie Le, Bo Pang, Hanyong Peng, Yiren Cao, Jinjun Wu, Ghulam Abbas, Jin Song, Dian-Bing Wang, Mengmeng Cui, Jeffery Tao, D. Lome, Tyrrell, Xian-En Zhang*, Hongquan Zhang*, X. Chis Le*. Molecular Diagnosis of COVID-19: Challenges and Research Needs. Analytical Chemistry, 2020,15(92),10196-10209. 6.Xia Li, Dianbing Wang, Zongqiang Cui, Qin Li, Min Li, Yinxin Ma, Qinxue Hu, Yikai Zhou*, Xian-En Zhang*. HIV-1 viral cores enter the nucleus collectively through the nuclear endocytosis-like pathway. SCIENCE CHINA-Life Sciences, 2020, DOI: 10.1007/s11427-020-1716-x 7.Jin Song, Yiwei Li, Fang Yin, Zhitao Zhang, Dingkun Ke, Dian-bing Wang, Qipeng Yuan*, Xian-En Zhang*. Enhanced Electrochemical Impedance Spectroscopy Analysis of Microbial Biofilms on an Electrochemically In Situ Generated Graphene Interface. ACS sensors, 2020, 5(6) 1795-1803. 8.Xian-En Zhang*. Nanobiology-Symphony of bioscience and nanoscience. SCIENCE CHINA-LIFE SCIENCES, 2020,8(63), 1099-1102. 9.Yiwei Li, Juan Zhou, Jin Song, Xiaosheng Liang, Zhiping Zhang, Dong Men*, Dianbing Wang, Xian-En Zhang*. Chemical Nature of Electrochemical activation of Carbon Electrodes. Biosensors & Bioelectronics, 2020,149, 111874. 10.Lin Huang, Ning Gu, Xian-En Zhang*, Dian-Bing Wang* (2019). Light-Inducible Exosome-Based Vehicle for Endogenous RNA Loading and Delivery to Leukemia Cells. Advanced Functional Materials, 29(9):1807189. 11.Yan Xi, Dian-Bing Wang, Tingting Wang, Lin Huang, Xian-En Zhang* (2019). Quantitative Profiling of CD13 on Single Acute Myeloid Leukemia Cells by Super-resolution imaging and its Implication in Targeted Drug Susceptibility Assessment. Nanoscale, 11(4):1737-1744. 12.Dongge Guo, Dian-Bing Wang, Chong Liu, Song Lu, Yu Hou, Xian-En Zhang* (2019). CRISPR-based genomic loci labeling revealed ordered spatial organization of chromatin in living diploid human cells. BBA-Molecular Cell Research, 1866(12):118518. 13.Lingling Li, Chengchen Xu, Wenjing Zhang, Francesco Secundo, Chunyan Li, Zhi-Ping Zhang, Xian-En Zhang*, Feng Li* (2019). Cargo-Compatible Encapsulation in Virus-Based Nanoparticles. Nano Letters, 19(4):2700-2706. 14.Tingting Wang, Guang Li, Dianbing Wang, Feng Li, Dong Men, Tao Hu, Yan Xi, and Xian-En Zhang* (2019). Quantitative profiling of integrin αvβ3 on single cells with quantum dot labeling to reveal the phenotypic heterogeneity of glioblastoma. Nanoscale, 11(39):18224-18231. 15.Yiwei Li, Juan Zhou, Jin Song, Xiaosheng Liang, Zhiping Zhang, Dong Men*, Dianbing Wang, Xian-En Zhang* (2019). Chemical Nature of Electrochemical activation of Carbon Electrodes. Biosensors & Bioelectronics, 144: 111534. 16.Sha Wei, Dianbing Wang, Hua Li, Lijun Bi, Jiaoyu Deng, Guofeng Zhu, Jibin Zhang, Chuanyou Li, Min Li, Yuan Fang, Guimin Zhang, Jian Chen, Shengce Tao, Xian-En Zhang* (2019). Fatty acylCoA synthetase FadD13 regulates proinflammatory cytokine secretion dependent on the NF‐κB signalling pathway by binding to eEF1A1. Cellular Microbiology, e13090. 17.Yuanyuan Chen, Zhengyan Zhan, Hongtai Zhang, Lijun Bi, Xian-En Zhang*, Yu Vincent Fu* (2019). Kinetic analysis of DNA compaction by mycobacterial integration host factor at the single-molecule level. Tuberculosis, 119, 101862. 18.黄琳,王殿冰,顾宁,张先恩* (2019). 高效装载细胞内源蛋白工程化外泌体的构建. 生物工程学报,(8):1537-1545. 19.Xian-En Zhang* (2018). Forty years of highly synchronous development in China’s scientific research and economy. National Science Review, 5 (6): 796–798. 20.Fan Yang, Xiaolei Zuo, Chunhai Fan*, Xian-En Zhang* (2018). Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing. National Science Review, 5 (5): 740–755. 21.Lin Huang, Dian-Bing Wang, Netrapal Singh, Fang Yang, Ning Gu*, Xian-En Zhang* (2018). A dual-signal amplification platform for sensitive fluorescence biosensing of leukemia-derived exosomes. Nanoscale, 10(43): 20289-20295. 22.Ye Yuan, Dian-Bing Wang, Jibin Zhang, Ji Liu, Jian Chen, Xian-En Zhang* (2018). Raman spectra of the GFP-like fluorescent proteins. Biophysics reports, 4(5): 265-272. 23.Dong Men, Juan Zhou, Wei Li, Cui-Hua Wei, Yuan-yuan Chen, Kun Zhou, Ying Zheng, Ke Xu, Zhi-Ping Zhang, Xian-En Zhang* (2018). Self-Assembly of Antigen Proteins into Nanowires Greatly Enhances the Binding Affinity for High-Efficiency Target Capture. ACS Appl Mater Interfaces, 10(48):41019-41025. 24.Yingxin Ma, Mingxiu Wang, Wei Li, Zhiping Zhang, Xiaowei Zhang, Guoqiang Wu, Tianwei Tan, Zongqiang Cui*, Xian-En Zhang* (2017). Live Visualization of HIV-1 Proviral DNA Using a Dual-Color-Labeled CRISPR System. Analytical Chemistry, 89(23): 12896-12901. 25.Qin Li, Wei Li, Wen Yin, Jia Guo, Zhi-Ping Zhang, Dejun Zeng, Xiaowei Zhang, Yuntao Wu, Xian-En Zhang*, and Zongqiang Cui* (2017). Single-Particle Tracking of Human Immunodeficiency Virus Type 1 Productive Entry into Human Primary Macrophages. Acs Nano, 11(4):3890-3903. 20. Yingxin Ma, Mingxiu Wang, Wei Li, Zhiping Zhang, Xiaowei Zhang, Tianwei Tan, Xian-En Zhang* & Zongqiang Cui* (2017). Live cell imaging of single genomic loci with quantum dot-labeled TALEs. Nature Communications, 8:15318. 26.Kun Li, Ting Li, Shan-shan Yang, Xu-De Wang, Lei-xin Gao, Rui-Qi Wang, JingGu, Xian-En Zhang*, Jiao-Yu Deng* (2017). Deletion of nudB causes increased susceptibility to antifolates in Escherichia coli and Salmonella enterica. Antimicrobial Agents & Chemotherapy, 61(5):02378-16. 27.Hua Li, Sha Wei, Yuan Fang, Min Li, Xia Li, Zhe Li, Jibin Zhang, Guofeng Zhu, Chuanyou Li, Lijun Bi, Guimin Zhang, Dianbing Wang,* and Xian-En Zhang* (2017).Quantitative proteomic analysis of host responses triggered by Mycobacterium tuberculosis infection in human macrophage cells. ABBS, 49 (9):835-844. 28.Zhitao Zhang, Dianbing Wang, Chuanyou Li, Jiaoyu Deng, Jibin Zhang, Lijun Bi and Xian-En Zhang* (2017). Microbial sensor for drug susceptibility testing of Mycobacterium tuberculosis. J Appl. Microbiol, 124(1): 286-293. 29.张先恩* (2017). 生物传感发展50年及展望. 中国科学院院刊, 32(12):1271-1280. 30.王殿冰, 崔宗强, 张先恩* (2017). 分子生物传感器与细胞内分子影像. 中国科学院院刊, 32(12):1303-1312. 31.Xianxun Sun, Wei Li, Xiaowei Zhang, Mi Qi, Zhiping Zhang, Xian-En Zhang*, Zongqiang Cui* (2016). In Vivo Targeting and Imaging of Atherosclerosis Using Multifunctional Virus-Like Particles of Simian Virus 40. Nano Letters, 16:6164-6171. 32.Yingxin Ma, Zhike He, Tianwei Tan, Wei Li, Zhiping Zhang, Shuang Song, Xiaowei Zhang, Qinxue Hu, Peng Zhou, Yuntao Wu, Xian-En Zhang* and Zongqiang Cui* (2016). Real-Time Imaging of Single HIV-1 Disassembly with Multicolor Viral Particles. ACS Nano, 10: 6273-6282 33.Minghai Chen, Sanying Liu, Wei Li, Zhiping Zhang, Xiaowei Zhang, Xian-En Zhang*, Zongqiang Cui* (2016). Three-Fragment Fluorescence Complementation Coupled with Photoactivated Localization Microscopy for Nanoscale Imaging of Ternary Complexes. ACS Nano, 10: 8482-8490. 34.Dong Men*, Juan Zhou, Wei Li, Yan Leng, Xinwen Chen, Sheng-ce Tao, Xian-En Zhang* (2016). Fluorescent Protein Nanowire-Mediated Protein Microarrays for Multiplexed and Highly Sensitive Pathogen Detection. ACS Applied Matrrials & Interfaces, 8:17472-17477. 35.Xian-En Zhang*, Zongqiang Cui, Dianbing Wang (2016). Sensing of biomolecular interactions using fluorescence complementing systems in living cells. Biosensors & Bioelectronics, 76:243-250.
36.ZhaoYang Li, ZhiPing Zhang, LiJun Bi, ZongQiang Cui, JiaoYu Deng, DianBing Wang*, Xian-En Zhang* (2016). Mutagenesis of mNeptune Red-Shifts Emission Spectrum to 681-685 nm. PLOS ONE, 11(4):e0148749. |
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