石正丽

研究方向

动物源新发传染病病原学及跨种感染风险预警研究。

教育及工作经历

1983.09-1987.07 武汉大学生物系遗传专业，理学学士

1987.09-1990.07 中国科学院武汉病毒研究所，硕士研究生

1996.10-2000.05 法国蒙彼利埃第二大学，博士研究生

2000.10-2006.12 中国科学院武汉病毒研究所，研究员

2006.02-2006.05 澳大利亚动物健康研究室，高级访问学者

2006.09-2006.10 法国里昂P4实验室，访问学者

2007.01-至今中国科学院武汉病毒研究所，研究员

近五年承担项目

1.国家自然基金委新冠专项

2. 国家自然基金委国际合作项目

3.国家科技重点研发计划项目

近五年代表性论文

1. Liu MQ#, Lin HF#, Li J, Chen Y, Luo Y, Zhang W, Hu B, Tian FJ, Hu YJ, Liu YJ, Jiang RD, Gong QC, Li A, Guo ZS, Li B, Yang XL, Tong YG, Shi ZL*. 2023. A SARS-CoV-2-Related Virus from Malayan Pangolin Causes Lung Infection without Severe Disease in Human ACE2-Transgenic Mice. J Virol 97:e0171922.

2. Chen# J, Yang X#, Si H#, Gong Q#, Que T#, Li J, Li Y, Wu C, Zhang W, Chen Y, Luo Y, Zhu Y, Li B, Luo D, Hu B, Lin H, Jiang R, Jiang T, Li Q, Liu M, Xie S, Su J, Zheng X, Li A, Yao Y, Yang Y, Chen P, Wu A, He M, Lin X*, Tong Y*, Hu Y*, Shi ZL*, Zhou P*. 2023. A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry. Cell 186:850-863 e16.

3. Guo H, Li A, Dong TY, Su J, Yao YL, Zhu Y, Shi ZL*, Letko M*. 2022. ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells. mBio 13:e0256622.

4. Chen Y, Jiang R-D, Wang Q, Luo Y, Liu M-Q, Zhu Y, Liu X, He Y-T, Zhou P, Yang X-L, Shi ZL*. 2022. Lethal swine acute diarrhea syndrome coronavirus infection in suckling mice. J Virol 96(17):e0006522.

5. Guo H, Li A, Lin H-F, Liu M-Q, Chen J, Jiang T-T, Li B, Wang Y, Letko MC, Peng W*, Shi ZL*. 2022. The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint. J Virol 96(15):e0095822.

6. Liu M-Q#, Jiang R-D#, Guo J#, Chen Y#, Yang D-S, Wang X, Lin H-F, Li A, Li B, Hu B, Wang Z-J*, Yang X-L*, Shi ZL*. 2022. Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice. J Virol 96(8):e0016922.

7. Li Y#, Wang X#, Shen X-R, Geng R, Xie N, Han J-F, Zhang Q-M, Shi ZL*, Zhou P*. 2022. A 1-year longitudinal study on COVID-19 convalescents reveals persistence of anti-SARS-CoV-2 humoral and cellular immunity. Emerg Microbes Infect 11(1):902-913.

8. Guo H#, Hu B#, Si HR, Zhu Y, Zhang W, Li B, Li A, Geng R, Lin HF, Yang XL, Zhou P*, Shi ZL*. 2021. Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor. Emerg Microbes Infect 10(1):1507-1514.

9. Jiang RD#, Liu MQ#, Chen Y#, Shan C, Zhou YW, Shen XR, Li Q, Zhang L, Zhu Y, Si HR, Wang Q, Min J, Wang X, Zhang W, Li B, Zhang HJ, Baric RS, Zhou P, Yang XL*, Shi ZL*. 2020. Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. Cell 182:50-58 e8.

10. Zhou P#, Yang XL#, Wang XG#, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL*. 2020. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579:270-273.