李峰

研究方向

病毒样颗粒等生物纳米材料的可控组装与精准功能化

病毒启发的智能递送系统

新型纳米疫苗

面向病毒学的微纳分析新技术

教育及工作经历

2000.09-2004.07山东大学，生物技术专业，学士

2004.09-2009.07中国科学院武汉病毒研究所，微生物学专业，博士

2009.07-2009.11中国科学院苏州纳米技术与纳米仿生研究所，助理研究员

2009.12-2011.12中国科学院苏州纳米技术与纳米仿生研究所，博士后

2012.01-2013.08中国科学院苏州纳米技术与纳米仿生研究所，副研究员

2013.09-现在中国科学院武汉病毒研究所，研究员

近五年承担项目

1.国家重点研发计划课题

课题名称：重要病毒感染致病动态规律及其分子机制研究

执行年限：2022.12-2025.11

承担角色：负责人

2.国家自然科学基金重大项目课题

课题名称：病毒侵染细胞全过程动态示踪

执行年限：2023.01-2027.12

承担角色：骨干

3.武汉市重大科技专项子课题

子课题名称：非洲猪瘟组合抗原纳米疫苗研发

执行年限：2023.09-2026.09

承担角色：负责人

4.武汉市知识创新专项项目，基础研究项目

课题名称：多功能VLP介导的肿瘤催化、放射与免疫协同治疗

执行年限：2022.06-2024.06

承担角色：负责人

5.中国科学院科研装备研制项目

课题名称：病毒活细胞感染动力学分析系统

执行年限：2020.01-2021.12

承担角色：负责人

6.中国科学院院重点部署项目

课题名称：非洲猪瘟组合抗原纳米疫苗构建

执行年限：2019.01-2020.12

承担角色：负责人

7.国家自然科学基金面上项目

课题名称：利用磁垂钓技术研究蛋白纳米笼在活体内的蛋白冠效应

执行年限：2018.01-2021.12

承担角色：负责人

近五年代表性论文

1. Ao Liang, Wei Zhou, Hui Zhang, Juan Zhang, Xian-En Zhang, Ti Fang*, Feng Li*. Effects of Individual Amino Acids on the Blood Circulation of Biosynthetic Protein Nanocages: Toward Guidance on Surface Engineering. Advanced Healthcare Materials. 12(26): 2300502 (2023) (Inside back cover paper)

2. 王玹, 万颖, 张先恩, 徐承晨*, 李峰*. 基于病毒样颗粒的mRNA递送系统研究进展. 科学通报，10.1360/TB-2023-0632 (2023)

3. Quan Cheng, Xuan Wang, Xian-En Zhang, Chengchen Xu*, Feng Li*. Quantitative functionalization of biosynthetic caged protein materials. Qantitative Biology. 11(1): 1-14 (2023)

4. Ti Fang, Chaoqun Li, Ao Liang, Hui Zhang, Fan Zhang, Xian-En Zhang, Yi-Yu Yang*, and Feng Li*. Probing cell membrane integrity using a histone-targeting protein nanocage displaying precisely positioned fluorophores. Nano Research. 16, 894-904 (2023)

5. Xuehong Min, Ming Li, Wenjing Zhang, Run-Hao Li, Zhe Zhang, Pingshan Wang, Weide Su, Feng Li*, Yue Sun*, and Yi Liu*. Pt(II) metallacycles encapsulated by ferritin enable precise cancer combination chemo-photodynamic therapy. Journal of Materials Chemistry B. 11, 1090-1099 (2023)

6. Jingya Tang, Guimin Zhang, Feng Li, Rongyu Zeng, Jin Song, Ghulam Abbas, Mengmeng Cui, Wei Zhang, Xian-En Zhang*, and Dian-Bing Wang*. Two-Dimensional Protein Nanoarray as a Carrier of Sensing Elements for Gold-Based Immunosensing Systems. Analytical Chemistry. 94, 26, 9355-9362 (2022)

7. 李峰, 张先恩. 纳米合成生物学：融合创新的新维度. 合成生物学, 3(2): 253-255 (2022)

8. Weide Su, Jingjiang Qiu, Ying Mei, Xian-En Zhang*, Yong He* and Feng Li*. A microfluidic cell chip for virus isolation via rapid screening for permissive cells. Virologica Sinica. 37 (4), 547-557 (2022)

9. Ruimin Gao#, Huan Tan#, Shanshan Li#, Shaojie Ma, Yufu Tang, Kaiming Zhang, Zhiping Zhang, Quli Fan, Jun Yang*, Xian-En Zhang*, Feng Li*. A prototype protein nanocage minimized from carboxysomes with gated oxygen permeability. Proceedings of the National Academy of Sciences of the United States of America, 119 (5) e2104964119 (2022)

10. Wenjing Zhang, Qingyan Jia, Yibo Teng, Mengsi Yang, Hui Zhang, Xian-En Zhang, Pengfei Wang, Jiechao Ge*, Sheng Cao*, Feng Li*. An Ultrastable Virus-Like Particle with a Carbon Dot Core and Expanded Sequence Plasticity. Small. 17 (35), 2101717 (2021)

11. Juan Zhang, Wenjing Zhang, Mengsi Yang, Weiwei Zhu, Ming Li, Ao Liang, Hui Zhang, Ti Fang, Xian-En Zhang and Feng Li*. Passive cancer targeting with a viral nanoparticle depends on the stage of tumorigenesis. Nanoscale. 13, 11334-11342 (2021)

12. Ruimin Gao, Xian-En Zhang, Feng Li*. Generation and characterization of self-assembled protein nanocages based on β-carboxysomes in Escherichia coli. Acta Biochimica et Biophysica Sinica. 53, 943–949 (2021)

13. Xuehong Min, Juan Zhang, Run-Hao Li, Fangfang Xia, Shi-Qi Cheng, Ming Li, Weiwei Zhu, Wei Zhou, Feng Li*, and Yue Sun*. Encapsulation of NIR-II AIEgens in Virus-like Particles for Bioimaging. ACS Applied Materials & Interfaces. 13, 15, 17372–17379 (2021)

14. Weiwei Zhu, Ti Fang, Wenjing Zhang, Ao Liang, Hui Zhang, Zhi-Ping Zhang, Xian-En Zhang, Feng Li*. A ROS scavenging protein nanocage for in vitro and in vivo antioxidant treatment. Nanoscale. 13, 4634-4643 (2021)

15. Mariana B. Oliveira, Feng Li, Jonghoon Choi, João F. Mano. Nanomaterials for Biomedical Applications. Biotechnology Journal. 15: 2000574 (2020) (Editorial)

16. 张文静，李明，周维，张先恩，李峰*. 基于病毒组件的纳米材料的自组装合成、功能化及应用. 合成生物学. 1(3): 298-318. (2020)

17. Chengchen Xu, Weiwei Zhu, Hanjing Mao, Wenjing Zhang, Gen-Quan Yin*, Xian-En Zhang*, Feng Li*. Switch from polymorphic to homogenous self-assembly of virus-like particles of simian virus 40 through double-cysteine substitution. Small. 16(45): 2004484 (2020) (Back cover paper)

18. Feng Li*, Dianbing Wang, Juan Zhou, Dong Men and Xian-En Zhang*. Design and biosynthesis of functional protein nanostructures. Science China Life Sciences. 63: 1142–1158 (2020) 

19. Xuehong Min, Ti Fang, Lingling Li, Chaoqun Li, Zhi-Ping Zhang, Xian-En Zhang and Feng Li*. AIE nanodots scaffolded by mini-ferritin protein for cellular imaging and photodynamic therapy. Nanoscale. 12, 2340-2344 (2020)

20. Ti Fang, Weiwei Zhu, Chaoqun Li, Fan Zhang, Ding Gao, Zhi-Ping Zhang, Ao Liang, Xian-En Zhang* and Feng Li*. Role of Surface RGD Patterns on Protein Nanocages in Tumor Targeting Revealed Using Precise Discrete Models. Small. 15: 1904838 (2019)

21. Lingling Li, Chengchen Xu, Wenjing Zhang, Francesco Secundo, Chunyan Li, Zhi-Ping Zhang, Xian-En Zhang* and Feng Li*. Cargo-Compatible Encapsulation in Virus-Based Nanoparticles. Nano Letters. 19(4): 2700-2706 (2019)