Yangbo HU

Title: Principal Investigator E-mail: ybhu@wh.iov.cn

Education

2002-2006, Bachelor, Wuhan University, Biotechnology

2006-2011, Ph.D, Wuhan Institute of Virology, CAS, Microbiology



Research Interests

We are interested in following areas: 1) Mechanisms of bacterial drug-resistance; 2) Novel molecules targeting drug-resistant pathogens; 3) Diseases controlling with engineered probiotics.



Publications

1.        Huang S, Zhou W, Tang W, Zhang Y, Hu Y*, Chen S*. Genome-scale analyses of transcriptional start sites in Mycobacterium marinum under normoxic and hypoxic conditions. BMC Genomics. 2021.


2.        Liu L, Huang S, Fei K, Zhou W, Chen S*, Hu Y*. Characterization of the binding motif for the T3SS master regulator LcrF in Yersinia pseudotuberculosis. FEMS Microbiol Lett. 2021 Mar 11;fnab031.doi: 10.1093/femsle/fnab031.


3.        Zhang B, Yu B, Zhou W, Wang Y, Sun Z, Wu X, Chen S, Ni M*, Hu Y*. Mobile Plasmid Mediated Transition From Colistin-Sensitive to Resistant Phenotype in Klebsiella pneumoniae. Front Microbiol. 2021 Feb 15;12:619369.


4.        Shi W#, Zhou W#, Zhang B, Huang S, Jiang Y, Schammel A, Hu Y*, Liu B*. Structural basis of bacterial σ28-mediated transcription reveals roles of the RNA polymerase zinc-binding domain. EMBO J. 2020 Jul 15;39(14):e104389.


5.        Tu W#, Tang W#, Yu L#, Liu Z, Liu Y, Xia H, Zhang H, Chen S, Wu J, Cui X, Zhang J, Wang F*, Hu Y*, Deng D*. Inactivating SARS-CoV-2 by electrochemical oxidation. Sci Bull (Beijing). 2020 Dec 30. doi.org/10.1016/j.scib.2020.12.025


6.        Mao C, Zhu Y, Lu P, Feng L, Chen S*, Hu Y*. Association of ω with the C-Terminal Region of the β' Subunit Is Essential for Assembly of RNA Polymerase in Mycobacterium tuberculosis. J Bacteriol. 2018 May 24;200(12):e00159-18.


7.        Wang Z, Cumming BM, Mao C, Zhu Y, Lu P, Steyn AJC, Chen S*, Hu Y*. RbpA and σB association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance. Mol Microbiol. 2018 Jun;108(6):627-640.


8.        Feng L, Chen S*, Hu Y*. PhoPR Positively Regulates whiB3 Expression in Response to Low pH in Pathogenic Mycobacteria. J Bacteriol. 2018 Mar 26;200(8):e00766-17.


9.        Zhu Y#, Mao C#, Ge X, Wang Z, Lu P, Zhang Y, Chen S, Hu Y*. Characterization of a Minimal Type of Promoter Containing the -10 Element and a Guanine at the -14 or -13 Position in Mycobacteria. J Bacteriol. 2017 Oct 3;199(21):e00385-17.


10.    Hu Y#, Wang Z#, Feng L, Chen Z, Mao C, Zhu Y, Chen S*. σE-dependent activation of RbpA controls transcription of the furA-katG operon in response to oxidative stress in mycobacteria. Mol Microbiol. 2016 Oct;102(1):107-20.


11.    Feng L, Chen Z, Wang Z, Hu Y*, Chen S*. Genome-wide characterization of monomeric transcriptional regulators in Mycobacterium tuberculosis. Microbiology (Reading). 2016 May;162(5):889-897.


12.    Li Y#, Hu Y#, Francis MS, Chen S*. RcsB positively regulates the Yersinia Ysc-Yop type III secretion system by activating expression of the master transcriptional regulator LcrF. Environ Microbiol. 2015 Apr;17(4):1219-33.


13.    Hu Y, Morichaud Z, Perumal AS, Roquet-Baneres F, Brodolin K*. Mycobacterium RbpA cooperates with the stress-response σB subunit of RNA polymerase in promoter DNA unwinding. Nucleic Acids Res. 2014;42(16):10399-408.


14.    Li Y, Li L, Huang L, Francis MS, Hu Y*, Chen S*. Yersinia?Ysc-Yop type III secretion feedback inhibition is relieved through YscV-dependent recognition and secretion of LcrQ. Mol Microbiol. 2014 Feb;91(3):494-507.


15.    Hu Y, Morichaud Z, Chen S, Leonetti JP, Brodolin K*. Mycobacterium tuberculosis RbpA protein is a new type of transcriptional activator that stabilizes the σA-containing RNA polymerase holoenzyme. Nucleic Acids Res. 2012 Aug;40(14):6547-57.