Weiwei LUO

Title: Professor E-mail: wwluo@wh.iov.cn

Education
Ph.D.  2011-2016  Wuhan University, Wuhan, China   
B.S.    2006-2010  Wuhan University, Wuhan, China  


Research Interests

In the battle between a virus and its host, innate immunity serves as the first line of defense protecting the host against pathogens, which is induced by detecting the signs of pathogen infection and cellular danger signals by pattern recognition receptors (PRRs) on host cells. In some cases, however, this protective immune response can trigger excessive inflammation that damages tissues and causes many autoimmune/autoinflammatory symptoms. In the past five years, our main goal is to discover molecular mechanisms of how the innate immune system timely initiates efficient innate immune response without induction of autoimmunity. Another research interest is to reveal the relationship between innate immune response and core metabolism pathway in virus-infected cells, and the roles of their relationship in the pathogenesis of infectious and metabolic diseases. Recently, we have also focused on the pathogenic mechanism of some important viruses, such as SARS-COV-2. 

In summary, our long-term goal is to better understand the molecular mechanisms of host-pathogen interactions, which ultimately will help identify molecular targets for immunotherapeutic treatment of pathogenic and inflammatory diseases.



Publications

1.      Zhang, H.Y., Liao, B.W., Xu, Z.S., Ran, Y., Wang, D.P., Yang, Y., Luo, W.W*., and Wang, Y.Y*. (2020). USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA. PLoS Pathog 16, e1008178.


2.      Cao, P., Luo, W.W*., Li, C., Tong, Z., Zheng, Z.Q., Zhou, L., Xiong, Y., and Li, S*. (2019). The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors. PLoS Pathog 15, e1007983.


3.      Luo, W.W., and Shu, H.B. (2018). Delicate regulation of the cGAS-MITA-mediated innate immune response. Cell Mol Immunol 15, 666-675.


4.      Luo, W.W., and Shu, H.B. (2017). Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses. FEBS Lett 591, 3182-3189.


5.      Luo, W.W., Li, S., Li, C., Zheng, Z.Q., Cao, P., Tong, Z., Lian, H., Wang, S.Y., Shu, H.B., and Wang, Y.Y. (2017). iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. PLoS Pathog 13, e1006693.


6.      Luo, W.W., Li, S., Li, C., Lian, H., Yang, Q., Zhong, B., and Shu, H.B. (2016). iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol 17, 1057-1066.


7.      Luo, W.W., Lian, H., Zhong, B., Shu, H.B., and Li, S. (2016). Kruppel-like factor 4 negatively regulates cellular antiviral immune response. Cell Mol Immunol 13, 65-72.