Feng LI

Title: Principal Investigator E-mail: fli@wh.iov.cn


Feng Li received BS from Shandong University in 2004, and PhD from WIV, CAS in 2009. 

Research Interests

His research interests are protein nanostructures and their applications in templated-assembly of functional nanoarchitectures for delivery, sensing, etc.


1.   Zhu, W.#; Fang, T.#; Zhang, W.; Liang, A.; Zhang, H.; Zhang, Z.-P.; Zhang, X.-E.; Li, F.*, A ROS scavenging protein nanocage for in vitro and in vivo antioxidant treatment. Nanoscale (2021) DOI: 10.1039/D0NR08878A

2.   Chengchen Xu, Weiwei Zhu, Hanjing Mao, Wenjing Zhang, Gen-Quan Yin*, Xian-En Zhang*, Feng Li*. Switch from polymorphic to homogenous self-assembly of virus-like particles of simian virus 40 through double-cysteine substitution. Small. In press (10.1002/smll.202004484) (2020)

3.   Feng Li*, Dianbing Wang, Juan Zhou, Dong Men and Xian-En Zhang*. Design and biosynthesis of functional protein nanostructures. Science China Life Sciences. 63 (2020) DOI: 10.1007/s11427-019-1641-6

4.   Michele Dei Cas, Gabriella Roda, Feng Li, and Francesco Secundo*. Functional Lipids in Autoimmune Inflammatory Diseases. International Journal of Molecular Sciences. 21: 3074 (2020)

5.   Guochang Liu, Ming Fu, Feng Li, Wen Fu, Zhang Zhao, Huimin Xia*, and Yuqing Niu*. Tissue-engineered PLLA/gelatine nanofibrous scaffold promoting the phenotypic expression of epithelial and smooth muscle cells for urethral reconstruction. Materials Science and Engineering: C. 111: 110810 (2020)

6.   Xuehong Min, Ti Fang, Lingling Li, Chaoqun Li, Zhi-Ping Zhang, Xian-En Zhang and Feng Li*. AIE nanodots scaffolded by mini-ferritin protein for cellular imaging and photodynamic therapy. Nanoscale. 12, 2340-2344 (2020)

7.   Wenjing Zhang, Xian-En Zhang* and Feng Li*. Controlled Co-assembly of Viral Nanoparticles of Simian Virus 40 with Inorganic Nanoparticles: Strategies and Applications (Book chapter). Biomotors and Their Nanobiotechnology Applications (CRC Press). 2020, In press

8.    Ti Fang, Weiwei Zhu, Chaoqun Li, Fan Zhang, Ding Gao, Zhi-Ping Zhang, Ao Liang, Xian-En Zhang* and Feng Li*. Role of Surface RGD Patterns on Protein Nanocages in Tumor Targeting Revealed Using Precise Discrete Models. Small. 15: 1904838, 10.1002/smll.201904838. (2019)

9.    Tingting Wang#, Guang Li, Dianbing Wang*, Feng Li, Dong Men, Tao Hu, Yan Xi and Xian-En Zhang*. Quantitative profiling of integrin αvβ3 on single cells with quantum dot labeling to reveal the phenotypic heterogeneity of glioblastoma. Nanoscale, 11: 18224-18231 (2019)

10.  Lingling Li, Chengchen Xu, Wenjing Zhang, Francesco Secundo, Chunyan Li, Zhi-Ping Zhang, Xian-En Zhang* and Feng Li*. Cargo-Compatible Encapsulation in Virus-Based Nanoparticles. Nano Letters. 19(4): 2700-2706 (2019)

11.  Jigang Wang, Ti Fang, Ming Li, Wenjing Zhang, Zhiping Zhang, Xian-En Zhang* and Feng Li*. Intracellular delivery of peptide drugs using viral nanoparticles of bacteriophage P22: covalent loading and cleavable release. Journal of Materials Chemistry B. 6, 3716-3726 (2018)

12.  Wenjing Zhang, Xian-En zhang*, Feng Li*. Virus-based nanoparticles of simian virus 40 in the field of nanobiotechnology. Biotechnology Journal. 13(6): 1700619. (2018)

13.  Wenjing Zhang#, Chengchen Xu#, Gen-Quan Yin, Xian-En Zhang, Qiangbin Wang*, Feng Li*. Encapsulation of Inorganic Nanomaterials inside Virus-Based Nanoparticles for Bioimaging. Nanotheranostics.1(4): 358-368 (2017) (#equal contribution)

14. Wenjing Zhang, Zhi-Ping Zhang, Xian-En Zhang*, Feng Li*. Reaction inside a Viral Protein Nanocage: Mineralization on a Nanoparticle Seed after Encapsulation via Self-Assembly. Nano Research. 10(10): 3285-3294 (2017) (IF2015=8.893)

15.  Chunyan Li, Feng Li,* Yejun Zhang, Wenjing Zhang, Xian-En Zhang, and Qiangbin Wang*. Real-Time Monitoring Surface Chemistry-Dependent In Vivo Behaviors of Protein Nanocages via Encapsulating an NIR-II Ag2S Quantum Dot.   ACS Nano 9(12): 12255-12263. (2015)

16. Lingzhi Ma, Feng Li,* Ti Fang, Jianting Zhang, and Qiangbin Wang*. Controlled Self-Assembly of Proteins into Discrete Nanoarchitectures Templated by Gold Nanoparticles via Monovalent Interfacial Engineering. ACS Applied Materials & Interfaces 7(20):11024-11031. (2015)

17. Feng Li and Qiangbin Wang*. Fabrication of nanoarchitectures templated by virus-based nanoparticles: strategies and applications. Small 10(2): 230-245. (2014) (Back-cover paper; invited review)

18. Feng Li#, Huiling Chen#, Lingzhi Ma, Kun Zhou, Zhi-Ping Zhang, Chun Meng*, Xian-En Zhang* and Qiangbin Wang*. Insights into stabilization of a viral protein cage in templating complex nanoarchitectures: roles of disulfide bonds. Small 10(3): 536-543. (2014

19.  Feng Li, Huiling Chen, Yejun Zhang, Zhong Chen, Zhi-Ping Zhang, Xian-En Zhang* and Qiangbin Wang*. Three-dimensional gold nanoparticle clusters with tunable cores templated by a viral protein scaffold. Small 8(24): 3832-3838. (2012)

20. Feng Li, Ding Gao, Xiaomin Zhai, Yanhua Chen, Tao Fu, Dongmin Wu, Zhi-Ping Zhang, Xian-En Zhang* and Qiangbin Wang*. Tunable, discrete, three-dimensional hybrid nanoarchitectures. Angewandte Chemie International Edition 123(18): 4288-4291. (2011)

21. Feng Li, Yanhua Chen, Huiling Chen, Wei He, Zhi-Ping Zhang, Xian-En Zhang* and Qiangbin Wang*. Monofunctionalization of protein nanocages. Journal of the American Chemical Society 133(50): 20040-20043. (2011)

22. Feng Li#, Ke Li#, Zong-Qiang Cui, Zhi-Ping Zhang, Hong-Ping Wei, Ding Gao, Jiao-Yu Deng and Xian-En Zhang*. Viral coat proteins as flexible nano-building-blocks for nanoparticle encapsulation. Small 6(20): 2301-2308. (2010) 

23. Feng Li, Zhi-Ping Zhang, Jun Peng, Zong-Qiang Cui, Dai-Wen Pang, Ke Li, Hong-Ping Wei, Ya-Feng Zhou, Ji-Kai Wen and Xian-En Zhang*. Imaging viral behavior in mammalian cells with self-assembled capsid-quantum-dot hybrid particles. Small 5(6): 718-726. (2009) (Inside-cover paper; highlighted by Nature China)

24. Kun Zhou, Feng Li, Gaole Dai, Chun Meng and Qiangbin Wang*. Disulfide bond: dramatically enhanced assembly capability and structural stability of tobacco mosaic virus nanorods. Biomacromolecules 14(8): 2593-2600. (2013)

25. Yan Zhang, Yejun Zhang, Guosong Hong, Wei He, Kun Zhou, Kai Yang, Feng Li, Guangcun Chen, Zhuang Liu, Hongjie Dai and Qiangbin Wang*. Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice. Biomaterials 34(14): 3639-3646. (2013)

26. Ding Gao, Zhi-Ping Zhang, Feng Li, Dong Men, Jiao-Yu Deng, Hong-Ping Wei, Xian-En Zhang* and Zong-Qiang Cui*. Quantum dot-induced viral capsid assembling in dissociation buffer. International journal of nanomedicine 8: 2119. (2013)

27. Yan Zhang, Guosong Hong, Yejun Zhang, Guangcun Chen, Feng Li, Hongjie Dai* and Qiangbin Wang*. Ag2S quantum dot: A bright and biocompatible fluorescent nanoprobe in the second near-infrared window. ACS Nano 6(5): 3695-3702. (2012)

28. Tingjuan Wang, Zhi-ping Zhang, Ding Gao, Feng Li, Hong-ping Wei, Xiaosheng Liang, Zong-qiang Cui* and Xian-En Zhang*. Encapsulation of gold nanoparticles by simian virus 40 capsids. Nanoscale 3(10): 4275-4282. (2011)

29. Yaping Du, Bing Xu, Tao Fu, Miao Cai, Feng Li, Yan Zhang and Qiangbin Wang*. Near-infrared photoluminescent Ag2S quantum dots from a single source precursor. Journal of the American Chemical Society 132(5): 1470-1471. (2010)

30.  Miao Cai, Feng Li, Yan Zhang and Qiangbin Wang*. One-pot polymerase chain reaction with gold nanoparticles for rapid and ultrasensitive DNA detection. Nano Research 3(8): 557-563. (2010)