Zhenhua ZHENG

Title: Principal Investigator E-mail: zhengzh@wh.iov.cn


2005 -2011   Ph.D. in Biochemistry and Molecular Biology, Wuhan institute of virology, CAS 

2001 -2005   B.S. in Biological Engineering, College of life sciences, Hubei University

Research Interests
Infection and pathogenic mechanisms of arboviruses; Host adaptation and cross-species infection and transmission of zoonoses virus



1.         Yang J, Jing X, Yi W, Li XD, Yao C, Zhang B*, Zheng Z*, Wang H, Gong P*. Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses. Nucleic Acids Res. 2021 Feb 22;49(3): 1567-1580

2.         Sun J, Zhang W, Tan Z, Zheng C, Tang Y, Ke X, Zhang Y, Liu Y, Li P, Hu Q, Wang H, Mao P, Zheng Z* (2020) Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes, Virulence, 11:1, 113-131

3.         Wang T, Li P, Zhang Z, Liu Y, Tan Z, Sun J, Ke X, Miao Y, Luo D, Hu Q, Xu F, Wang H, Zheng Z* (2020) In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy. Theranostics; 10(14): 6430-6447

4.         Wei C, Zheng C, Sun J, Luo D, Tang Y, Zhang Y, Ke X, Liu Y, Zheng Z*, Wang H. (2019) Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein. Viruses. 11(1).

5.         Tan Z, Zhang W, Sun J, Fu Z, Ke X, Zheng C, Zhang Y, Li P, Liu Y, Hu Q, Wang H*, Zheng Z* (2018) ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. J Neuroinflammation. 15(1): 275

6.         Li P, Ke X, Wang T, Tan Z, Luo D, Miao Y, Sun J, Zhang Y, Liu Y, Hu Q, Xu F, Wang H*, Zheng Z*. (2018). Zika virus attenuation by codon pair deoptimization induces sterilizing immunity in mouse models. J Virol 92: e00701-18

7.         Li Q, Zheng Z*, Liu Y, Zhang Z, Liu Q, Meng J, Ke X, Hu Q, Wang H. (2016) 2C Proteins of Enteroviruses Suppress IKKβ Phosphorylation by Recruiting Protein Phosphatase 1. J Virol. 90:5141-51.

8.         Liu Y, Zheng Z*, Shu B, Meng J, Zhang Y, Zheng C, Ke X, Gong P, Hu Q, Wang H. (2016) SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. J Virol. 90:10472-10485.

9.         Zheng C, Zheng Z*, Sun J, Zhang Y, Wei C, Ke X, Liu Y, Deng L, Wang H. (2017) MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication. Sci Rep. 7:16422.

10.     Zheng Z, Ke X, Wang M, He S, Li Q, Zheng C, Zhang Z, Liu Y, Wang H *. (2013) Human microRNA hsa-miR-296-5p suppresses Enterovirus 71 replication by targeting the viral genome. J Virol., 87, 5645-5656.

11.     Zheng Z, Li H., Zhang Z., Meng J., Mao D., Bai B., Lu B., Mao P., Hu Q., Wang H*. (2011) Enterovirus 71 2C protein inhibits TNF-α mediated activation of NF-κB by suppressing IκB kinase β phosphorylation. J Immunol. 187,2202-2212.

12.     Zheng Z, Wang H. (2013) Tracking viral infection: will quantum dot encapsulation unveil viral mechanisms? Nanomedicine, 8,1225-1227

13.     Zhang Z, Zheng Z, Luo H., Meng J, Li H, Li Q, Zhang X, Ke X, Bai B, Mao P, Hu Q, Wang H.* (2012) Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter. J immunol 189,144-1153.

14.     Li H., Zheng Z, Zhou P, Zhang B, Shi Z, Hu Q, Wang H.* (2010) The cysteine protease domain 1 of porcine reproductive and respiratory syndrome virus nonstructural protein 2 antagonizes 3 IRF-3 activation. J Gen Virol 91, 2947-2958.

15.     Li Q, Zhang Z, Zheng Z, Ke X, Luo H,Hu Q, Wang H.* (2013) Identification and Characterization of Complex Dual Nuclear Localization Signals in Human Bocavirus NP1. J Gen Virol. 94,1335-1342

16.     Luo H, Zhang Z., Zheng Z, Ke X, Zhang X, Li Q, Liu Y, Bai B, Mao P, Hu Q, Wang H.* (2013) Human Bocavirus VP2 Upregulates IFN-β Pathway by Inhibiting Ring Finger Protein 125-Mediated Ubiquitination of Retinoic Acid-Inducible Gene-I. J immunol 191,660-669.

17.     Zhang X, Zheng Z., Shu B, Liu X , Zhang Z, Liu Y, Bai B, Hu Q, Mao P, * Wang H.*. (2013) Human astrocytic cells support persistent Coxsackievirus B3 infection J Virol. 87,12407-12421

18.     Wang M, Zheng Z*, Meng J, Wang H, He M, Zhang F, Liu Y, Hu B, He Z, Hu Q, Wang H*. 2015, In vivo study of immunogenicity and kinetic characteristics of a quantum dot-labelled baculovirus. Biomaterials. 64:78-87.