Manli WANG

Title: Professor E-mail:


2009.4                   PhD degree: Wuhan Institute of Virology, Chinese Academy of Sciences

2002.9                   Bachelor degree: Wuhan Polytechnic University

2007.3-2007.10     Visiting scientist; Department of Virology, Wageningen Agricultural University, the Netherlands

Research Interests

Baculoviruses, Bunayviruses, Coronaviruses: 1) viral envelope fusion protein-mediated entry mechanism; 2) virus infection and pathogenesis mechanism. 3) antiviral drug discovery and the action of drugs


1.      Liu J#, Li Y#, Liu Q#, Yao Q#, Wang X, Zhang H, Chen R, Ren L, Min J, Deng F, Yan B, Liu L, Hu Z*, Wang M*, Zhou Y*. Cell Discovery 2021. 7:17.

2.      Leng L, Cao R, Ma J, Lv L, Li W, Zhu Y, Wu Z, Wang M*, Zhou Y*, Zhong W*. Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples. Signal Transduct Target Ther. 2021.6:9.

3.     Wang M#, Cao R#, Zhang L#, Yang X#, Liu J, Xu M, Shi Z, Hu Z*, Zhong W*, Xiao G*. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020.30:269-271. 

4.     Liu J#, Cao R#, Xu M#, Wang X, Zhang H, Hu H, Li Y, Hu Z*, Zhong W*, Wang M*. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery. 2020. 6:16.

5.     Wang X#, Cao R#, Zhang H#, Liu J, Xu M, Hu H, Li Y, Zhao L, Li W, Sun X, Yang X, Shi Z, Deng F, Hu Z*, Zhong W*, Wang M*. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discovery. 2020. 6:28.

6.     Cao R#, Hu H#, Li Y#, Wang X, Xu M, Liu J, Zhang H,K Yan Y, Zhao L, Li W, Zhao T, Xiao D, Guo X, Li Y, Yang J, Hu Z*, Wang M*, Zhong W*. Anti-SARS-CoV-2 potential of artemisinins in vitro. ACS infectious Diseases. 2020. 6:2524–2531.

7.     Liu J#, Li Y#, Liu L#. Hu X, Wang X, Hu H, Hu Z, Zhou Y*, Wang M*. Infection of human sweat glands by SARS-CoV-2. Cell Discovery. 2020. 6: 84.

8.     Zhang H, Kuang W, Chen C, Shang Y, Ma X, Deng F, Wang H, Wang M*, Hu Z*.  Per Os Infectivity Factor 5 Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway. J Virol. 2020.94:e00615-20. 

9.     Wang Q, Yin M, Yuan C, Liu X, Hu Z*, Zou Z*, Wang M*. Identification of a Conserved Prophenoloxidase Activation Pathway in Cotton Bollworm Helicoverpa armigera. Front Immunol. 2020.11:785.

10.   Li Y, Hu L, Chen T, Chang M, Deng F, Hu Z, Wang H*, Wang M*. Host AAA+ ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis. J Virol. 2020. 94: e01674-19.

11.    Shao W#, He L, Deng F, Wang H, Vlak JM, Hu Z*, Wang M*. Mito‐docking: A Novel In Vivo Method to Detect Protein–Protein Interactions. Small Methods. 2019.3:1900010.

12.    Hu L, Li Y, Ning YJ, Deng F, Vlak JM, Hu Z, Wang H*, Wang M*. The major hurdle for effective baculovirus transduction into mammalian cells is passing early endosomes. J Virol. 2019.93:e00709-19.

13.    Liu J, Xu M, Tang B, Hu L, Deng F, Wang H, Pang DW, Hu Z, Wang M*, Zhou Y*. Single-Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus. Small. 2019.15:e1803788. 

14.    Zhang L, Wang B, Xin Q, Shang W, Shen S, Xiao G, Deng F, Wang H, Hu Z*, Wang M*. Quantitative proteomic analysis reveals unfolded protein response involved in severe fever with thrombocytopenia syndrome virus infection. J Virol. 2019.93.e00308-19.

15.    Wang M, Hu Z*. Cross-talking between baculoviruses and host insects towards a successful infection. Philos Trans R Soc Lond B Biol Sci. 2019. 374:20180324.

16.    Wang X, Shang Y, Chen C, Liu S, Chang M, Zhang N, Hu H, Zhang F, Zhang T, Wang Z, Liu X, Lin Z, Deng F, Wang H, Zou Z, Vlak JM, Wang M*, Hu Z*. Baculovirus Per Os Infectivity Factor Complex: Components and Assembly. J Virol. 2019.93: e02053-18. 

17.    Li Y, Shen S, Hu L, Deng F, Vlak JM, Hu Z, Wang H*, Wang M*. The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly. J Virol. 2018. 92: e02083-17.

18.   Wang M, Wang J, Yin F, Tan Y, Deng F, Chen X, Jehle JA, Vlak JM, Hu Z, Wang H*. Unraveling the entry mechanism of baculoviruses and its evolutionary implications. J Virol. 2014.88:2301-2311.

19.   Wang M, Yin F, Shen S, Tan Y, Deng F, Vlak JM, Hu Z, Wang H*. Partial functional rescue of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus infectivity by replacement of F protein with GP64 from Autographa californica multicapsid nucleopolyhedrovirus. J Virol. 2010. 84:11505-11514.

20.   Wang M, Tuladhar E, Shen S, Wang H, van Oers MM, Vlak JM*, Westenberg M. Specificity of baculovirus P6.9 basic DNA-binding proteins and critical role of the C terminus in virion formation. J Virol. 2010. 84:8821-8828.

21.   Wang#, Tan Y#, Yin F, Deng F, Vlak JM, Hu Z, Wang H*. The F-like protein Ac23 enhances the infectivity of the budded virus of gp64-null Autographa californica multinucleocapsid nucleopolyhedrovirus pseudotyped with baculovirus envelope fusion protein F. J Virol. 2008. 82:9800-9804.