Yanyi WANG

Title: Principal Investigator E-mail: wangyy@wh.iov.cn


2004, B.S.   College of Life Science, Peking University

2006, M.S.   School of Medicine, University of Colorado

2010, Ph.D.  Department of Microbiology, College of Life Science, Wuhan University

Research Interests

Innate immune response acts as the first line of host defense against viral infection. Germ line-encoded pattern-recognition receptors (PRRs) of the innate immune system recognize pathogen associated molecular patterns (PAMPs) derived from invading viruses, which triggers a series of cellular events, leading to the induction of type I interferons (IFNs) and proinflammatory cytokines. Our research is focused on molecular mechanisms of antiviral innate immunity and inflammation.

1. Li WW, Nie Y, Yang Y, Ran Y, Luo WW, Xiong MG, Wang SY, Xu ZS*, Wang YY*. Ubiquitination of TLR3 by TRIM3 signals its ESCRT mediated trafficking to the endolysosomes for innate antiviral response. PNAS, 2020, 117(38), 23707-23716.

2. Fu YZ#*, Wang SY#,Zheng ZQ#,Huang Y, Li WW,Xu ZS,Wang YY*. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. Cellular & Molecular Immunology.DOI: 10.1038/s41423-020-00571-x.

3. Wang DP,Zhang HY,Liao BW, Tong Z, Xu ZS,Wang YY*,Yang Y*. SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5. Virologica Sinica. DOI: 10.1007/s12250-020-00267-6.

4. Xu ZS#, Shu T #, Kang L #, Wu D#, Zhou X #, Liao BW , Sun XL, Zhou X, Wang YY*.Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients. Signal Transduction and Targeted Therapy,2020,5(1):100.DOI: 10.1038/s41392-020-0211-1.

5. Zou HM, Huang ZF, Yang Y, Luo WW, Wang SY , Luo MH, Fu YZ *,Wang YY*. Human Cytomegalovirus Protein UL94 Targets MITA to Evade Antiviral Immune Response. Journal of Virology, 2020 Apr 1. pii: JVI.00022-20. doi: 10.1128/JVI.00022-20. 

6. Xiong MG, Xu ZS, Luo WW, Li YH,Wang SY ,Wang YY*, Ran Y*.RNF152 positively regulatesTLR/IL-1R  signaling by enhancing signaling MyD88 oligomerizationo.EMBO Reports,(2020) 21: e48860. 

7. Zhang HY, Liao BW, Xu ZS, Ran Y, Wang DP, Yang Y, Luo WW* and Wang YY*.USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.PLoS Pathogens, 2019,16(1):e1008178. 

8. Ran Y*, Xiong MG, Xu ZS, Luo WW, Wang SY and Wang YY.YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking. Journal of Immunology ,2019,203(6)1560-1570.

9. Fu YZ,Guo Y,Zou HM,Su S,Wang SY,Yang Q, Luo MH, Wang YY*. Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response. PLoS Pathogens, 2019;15(5):e1007691. 

10. Xu ZS#,Zhang HX#,Li WW,Ran Y,Liu TT,Xiong MG,Li QL,Wang SY, Wu M,Shu HB,Xia HM, Wang YY*.FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis. PNAS, 2019.116(21):10447-10452.
11. Fu YZ,Su S,Zou HM,Guo Y,Wang SY,Li S,Luo MH, Wang YY*.Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-kB-Mediated Transcription.Journal of Virology,June 2019 93(11):e00181-19. 

12. Zhang HX#,Xu ZS#, Lin H,Li M, Xia T, Cui KS; WangSY,Li YJ, Shu HB*, Wang YY*.TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.Nature Communications, 2018,9:3441. 

13. Huang ZF, Zou HM, Liao BW, Zhang HY, Yang Y, Fu YZ, Wang SY, Luo MH, Wang YY*.Human Cytomegalovirus Protein UL31 Inhiibits DNA Sensing of cGAS to Mediate Immune Evasion.Cell Host&Microbe, 2018 Jul 11;24(1):69-80.e4. doi: 10.1016/j.chom.2018.05.007. Epub 2018 Jun 21. 

14. Xiong MG, Wang SY, Wang YY, Ran Y*. The Regulation of cGAS.Virologica Sinica,(2018)33:117-124. 

15. Luo WW, Li S, Li C, Zheng ZQ,Cao P,Tong Z, Lian H, Wang SY, Shu HB, Wang Y Y*. IRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. PLoS Pathogenes2017; 13(11): e1006693.
16. Nie Y, Ran Y, Zhang HY, Huang ZF, Pan ZY, Wang SY, Wang YY*.GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.PLoS Pathogens, 2017 Apr; 13(4): e1006328. 

17. Yang Y, Wang SY, Huang ZF, Zou HM, Yan BR, Luo WW, Wang YY*. The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. Cell Reserch, 2016,26(3):288-303. 

18. Ran Y, Zhang J, Liu L L, Pan ZY, Nie Y, Zhang HY, Wang YY*. Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response. Journal of Molecular Cell Biology, 2016, 8(1), 31–43. Epub 2015 Nov 26.